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Philips Healthcare
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Journal: Bioactive Materials
Article Title: Spatiotemporal reprogramming of cardiac lipid metabolism by platelet-engineered RNA therapy epigenetically modulate heart repair and regeneration
doi: 10.1016/j.bioactmat.2026.02.009
Figure Lengend Snippet: Platelet-mediated siCD36 delivery reduces fibrosis, preserves wall thickness, and restores cardiac function after I/R injury. (A-B) Masson's trichrome staining and quantification of collagen deposition showing extensive fibrosis in I/R hearts, attenuated by siCD36@MSNs and further reduced with siCD36@MSNs@Plt. The scale bar in the upper panel is 1 mm, and that in the lower panel is 100 μm. n = 6. (C-D) Hematoxylin and eosin (H&E) staining and quantification of left ventricular anterior wall (LVAW) thickness showing preservation of myocardial structure with siCD36 treatment, most pronounced in the siCD36@MSNs@Plt group. The scale bar in the upper panel is 1 mm, and that in the lower panel is 100 μm. n = 6. (E) Representative M-mode echocardiography images showing improved ventricular wall motion in siCD36-treated groups compared with untreated I/R. n = 6. (F-H) Quantification of left ventricular ejection fraction (LVEF), fractional shortening (FS), and cardiac output (CO) demonstrating functional recovery in siCD36-treated groups, with the strongest improvement in siCD36@MSNs@Plt. n = 6. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ns = non-significant.
Article Snippet:
Techniques: Staining, Preserving, Functional Assay